Marya Automatic Sterile Prefilled Syringe Filling Line with CIP/SIP System
Overview
The Marya Automatic Sterile Prefilled Syringe Filling Line with CIP/SIP System is designed for automated processing of disposable syringes in nest packaging, including unpacking, tearing, precise filling, and stoppering operations. This advanced system is specifically engineered for pharmaceutical production of sensitive aseptic products including vaccines, monoclonal antibodies, low molecular weight heparin, insulin, and hyaluronic acid formulations.
This machine accommodates various pre-filled syringe configurations - both bagged and nested formats, in either plastic or glass materials. And this line is divided into linear (can be equipped with bottle washer dryer), and RTU nest box (no bottle washer dryer, direct automatic unpacking). The system features a highly stable, speed-adjustable conveyor mechanism that maintains Class A sterile conditions throughout the filling process. With servo-driven precision control, it ensures smooth product handling and exceptional filling accuracy across the complete viscosity spectrum, from aqueous solutions to highly viscous formulations.
Our company has successfully implemented these systems in some international projects, including a pre-filled syringe filling production line in Malaysia, demonstrating our extensive experience in delivering reliable aseptic filling solutions. This project expertise ensures we can provide tailored systems that meet the most demanding pharmaceutical production requirements.
Performance Features
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Full GMP Compliance - Complete manufacturing process from design to commissioning strictly follows current GMP regulations for pharmaceutical production.
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Precision Automated Operation - Servo-controlled system handles all processes from tray unpacking to filling and plugging with ≤±1% accuracy and ≥99.9% pass rate.
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Flexible Production Capacity - Handles 2,000-30,000 syringes/hour (1ml-20ml range) with 2-10 configurable filling heads and multiple pump options (metal/peristaltic/ceramic).
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Advanced Contamination Control - Features laminar flow protection, frictionless transport, and servo-driven components positioned to minimize environmental pollution.
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Customizable Filling Solutions - Offers vacuum filling for viscous products, nitrogen blanketing for oxygen-sensitive solutions, and CIP/SIP cleaning systems.
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Optional Isolation Systems - Configurable with Open-RABS, Class 100 laminar flow, or complete isolator systems with BIBO technology.
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Smart Control & Monitoring - PLC-based automation with touch-screen interface, automatic volume calibration, and intelligent quality monitoring at key stations.
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Robotic Automation Options - Can integrate collaborative robots for fully automated film tearing, filling, plugging, and weighing processes.
| Suitable Product Range |
0.1-20ml
change specification parts properly |
| Power Supply |
380V 50Hz |
| Power |
4.1kw |
| Filling Error |
±1% |
| Compressed Air Pressure |
0.6~0.8Mpa 20m³/h |
| Auto Stoppering Rate |
≥99.9% |
| Single Machine Noise |
≤70db |
| Weight |
750kg |
| Dimension |
1630×1320×1700(mm) |
Successful Prefilled Syringe Filling Line Case
We did a successful prefilled syringe filling line in Malaysia. Malaysia client wanted to find a supplier who could integrate all resources. Other suppliers cannot provide a one stop solution. Only Marya can meet all the needs of clients and provide them with professional technical guidance.
About client: A listed pharmaceutical company in Malaysia.
Client needs: Plastic pre-filled syringe aseptic isolator filling production line and packing line.
Solution:The client wanted to find a supplier who could integrate all resources. Other suppliers cannot provide an one stop solution that can integrate high-capacity plastic pre-filled syringe fillingmachines (with CIP/SIP systems), isolators, screw rod labeling machines, packing lines, etc. In the end, only Marya can meet all the needs of clients and provide clients with professionaltechnical guidance, so the client finally chose our company to provide them with a time-saving and worry-free one-stop solution.
Packing material: Prefilled Syringes
Capacity: 12000pcs/h
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