Marya Multi Heads Pharmaceutical Sterile Injection Filling Machine Automatic Prefilled Syringe Filling Line with O-Rabs

Product Description

Marya Multi Heads Pharmaceutical Sterile Injection Filling Machine Automatic Prefilled Syringe Filling Line with O-rabs

Product Description

Production Introduction:

Aseptic prefilled syringe filling line is mainly used for the unpacking, tearing, filling, and stoppering of disposable syringes, cartridge bottles, and vial bottles in honeycomb trays of pharmaceutical factories, to achieve the filling and sealing of pharmaceutical solutions; Adopting a stable and speed-adjustable conveying system, it maintains A-level sterilization status after entering the filling system. Servo drive control ensures smooth transportation. High precision filling from water to high viscosity is achieved through servo control. The entire line design, materials, manufacturing, assembly, debugging, etc. all meet the requirements of the new GMP and FDA drug production specifications.

Applicable Industries:

This linkage production line is mainly used in the fields of biomedicine, antithrombotic drugs, aesthetic medicine industry, and is suitable for the production and packaging of sterile products such as vaccines, monoclonal antibodies, small molecule heparin, insulin, Hyaluronic acid, etc. The finished product can also be used in medical industries such as ophthalmology, dentistry, otology, orthopedics, and gynecology.

Performance Features

1. Wide range of applicable specifications, high production capacity, and high filling accuracy:

Applicable specifications	1ml-20ml (according to user provided specifications)
Production capacity	2000-30000 bottles/hour
Filling volume range	0.1ml-20ml
Number of filling heads	2-10 filling heads, selected according to production requirements
Filling accuracy	≤±1% (determined based on drug characteristics)
Qualified rate	≥99%

 

2. Mature technology, adopting industry-leading high-end technology, stable performance, and cost savings:

 

(1)Flexible layout, suitable for specific room conditions;

(2)Suitable for toxic substances up to OEB5 in isolators;

(3)Automatic online filter sterilization;

(4)Automatic stacking of nest boxes and trays;

(5)Camera based nest tray status recognition;

(6)Precise placement of push rods for greater sterility;
(7)Flexible Recipe Editor for Customized Processes;

(8)Visual control push rod installation to improve accuracy;
(9)Gripper/pusher technology for careful syringe removal and placing on conveyor;

(10)Visual inspection based on camera and light transmission;

(11)A variety of filling pump forms: metal pump, peristaltic pump, ceramic pump;

(12)Online detection: Rapid response in case of particle or glass defects;

(13)Online detection: improves safety and quality during the filling process;

(14)Vacuum stoppage technology, suitable for viscous liquids and coated rubber stoppers, to avoid residual bubbles after stoppering;

Integrated hydrogen peroxide sterilization system;

(15)Modular settings for rapid delivery and customization;

(16)Prefilled and sealed bottles, cartridge bottles, and vial bottles can be freely interchanged with high efficiency;

(17)The ultra clean sterile robot is adopted, with more simple mechanism, less pollution risk and high factor of safety;

(18)High compatibility, suitable for all box prefilled bottles, cartridge bottles, and vial bottles currently on the market;

(19)After plugging, the residual air volume is small, and the residual volume is less than 20μL (vacuum plug);

(20)Adopting a one-time filling system;

(21)Adopting liquid level filling technology to prevent liquid medicine splashing;
(22)Adopting fully automatic production control and equipped with core workstation intelligent detection device;

(23)Upstream can be connected with automatic unpacking machines and automatic unpacking machines, while downstream can be connected with vial bottle capping machines, prefilled and sealing light inspection machines, and rotary rod labeling machines;

(24)Automatically remove the syringe from the honeycomb tray and place it back using a combination of servo system and cylinder;

(25)During the transmission process, the rubber stopper has no friction with the contact surface of liquid medicine and bottom rail, and is always protected by laminar flow to avoid the generation of particles and the risk of contamination;

(26)The main transmission components of the equipment are servo-driven and located in the lower part of the machine frame, with precise positioning and avoiding environmental pollution;

 

3. Multiple functions are optional, customized according to your needs:

(1)The servo motor can be configured to control the filling pump for filling, with high filling accuracy and convenient adjustment;

(2)Configurable filling system CIP/SIP system;
(3)Configurable vacuum filling system for filling high viscosity products;

(4)A nitrogen filling unit can be configured to isolate the liquid medicine from oxygen;

(5)Capable of configuring high-performance no bottle no filling, no bottle no capping, and linkage bottle squeezing shutdown functions;

(6)Configurable Open-RABS isolation protection system and 100 level air purification laminar flow system;
(7)According to whether the customer's product has toxicity or activity, a fully enclosed sterile isolation (Isolator) system and a bag in bag out (BIBO) system can be configured;

(8)Multiple robot collaborative control technologies can be configured to fully automate the process of prefilled syringe film tearing, lining removal, filling, stoppering, weighing, and other related processes;

(9)The filling volume autocorrection function can be configured, and the filling volume calibration of the filling pump can be fully automated;

(10)Adopting high-precision color touch screen operation monitoring, PLC automatic control, automatic protection, mainframe variable frequency speed regulation and other control technologies for fully automatic control and monitoring of the production process;

(11)We can customize relevant products according to the actual needs of customers.

 

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