Marya GMP Standard Aseptic Pharma Veterinary Medicine Prefilled Syringe Filling Machine with O-Rabs System

• Customization: Available
• After-sales Service: Field Installation, Commissioning and Training
• Certification: CE, GMP, ISO, GMP, SGS
• Model NO.: MY-PFS
• Condition: New
• Customized: Customized
• Machine Type: Syringe Filling Machine
• Voltage: 220V
• Warranty: 1 Year
• Size: Max 150*115*50, Min 55*30*15mm
• Machine Size: 3500*1500*1800mm
• Driven Type: Electric
• Application: Chemical, Medical, Food
• Type: Pharmaceutical Packaging Machinery
• Finished Dosage Form: Liquid
• Precision: High Precision
• Computerized: Computerized
• Transport Package: Standard Export Package
• Specification: Standard/Customized
• Trademark: Marya
• Origin: China
• Production Capacity: 10000PCS/Month
• Package Size: 350.00cm * 150.00cm * 180.00cm
• Package Gross Weight: 3500.000kg

Product Description

Marya  GMP Standard Aseptic Pharma Veterinary Medicine Prefilled Syringe Filling Machine with O-rabs System

Product Description

Overview

are mainly used for the unpacking, tearing, filling and plugging of disposable syringes in honeycomb trays in pharmaceutical plants, to achieve the filling and sealing of pharmaceutical solutions. Adopting a stable and speed-adjustable conveying system, it maintains A-level sterilization status after entering the filling system. Servo drive control ensures smooth transportation. High-precision filling from water to high viscosity is achieved through servo control.

Applicable Industries
This linkage production line is mainly used in the fields of biomedicine, antithrombotic drugs, aesthetic medicine industry, and is suitable for the production and packaging of sterile products such as vaccines, monoclonal antibodies, small molecule heparin, insulin, Hyaluronic acid, etc. The finished product can also be used in medical industries such as ophthalmology, dentistry, otology, orthopedics, and gynecology.

Production Advantages
1. Improve the usage rate of liquid medicine and reduce costs: Using this production line for one-time filling and sealing of liquid medicine can reduce the additional filling volume of liquid medicine, and the residual volume of liquid medicine during use is small, which can improve the usage rate of liquid medicine and effectively reduce costs.
2. Low equipment cost and low pollution risk: The aseptic prefilled syringe filling line adopts box syringe bottles no washing no sterilizing, cartridge bottles, and vial bottles, without the need for bottle cleaning and sterilization. Therefore, there is no need to configure cleaning machines, drying machines, and other equipment, which can reduce equipment costs and also reduce pollution risks.
3. Integrating filling and stoppering to ensure the quality of the liquid medicine: filling is followed by stoppering, resulting in a short exposure time of liquid medicine and low risk of contamination.
4. Vacuum plugging can be used: after plugging, there is less residual air and the residual volume is less than 20μL, which can meet condition that Drugs meet extremely high requirements for oxygen residue.
This production line is used for commercial production of medium or high volume syringes, providing a low risk and flexible processing method for sterile syringes. 
 

Technical Parameter

Suitable Product Range	0.1-20ml (change specification parts properly)
Power Supply	380V 50Hz
Power	4.4kw
Filling Error	+/-1%
Compress Air Pressure	0.6~0.8Mpa 20m^3/h
Auto Stoppering Rate	>=99.5%
Single Machine Noise	<=70db
Weight	750kg
Dimension	1630x1320x1700(mm)

 

Performance Features

1. Wide range of applicable specifications, high production capacity, and high filling accuracy:

Applicable specifications	1ml-20ml (according to user provided specifications)
Production capacity	2000-30000 bottles/hour
Filling volume range	0.1ml-20ml
Number of filling heads	2-10 filling heads, selected according to production requirements
Filling accuracy	≤±1% (determined based on drug characteristics)
Qualified rate	≥99%

 

2. Mature technology, adopting industry-leading high-end technology, stable performance, and cost savings:

(1)Flexible layout, suitable for specific room conditions;

(2)Suitable for toxic substances up to OEB5 in isolators;

(3)Automatic online filter sterilization;

(4)Automatic stacking of nest boxes and trays;

(5) Camera-based nest tray status recognition;

(6)Precise placement of push rods for greater sterility;
(7)Flexible Recipe Editor for Customized Processes;

(8)Visual control push rod installation to improve accuracy;
(9)Gripper/pusher technology for careful syringe removal and placing on conveyor;

(10)Visual inspection based on camera and light transmission;

(11)A variety of filling pump forms: metal pump, peristaltic pump, ceramic pump;

(12)Online detection: Rapid response in case of particle or glass defects;

(13)Online detection: improves safety and quality during the filling process;

(14)Vacuum stoppage technology, suitable for viscous liquids and coated rubber stoppers, to avoid residual bubbles after stoppering;

Integrated hydrogen peroxide sterilization system;

(15)Modular settings for rapid delivery and customization;

(16)Prefilled and sealed bottles, cartridge bottles, and vial bottles can be freely interchanged with high efficiency;

(17)The ultra clean sterile robot is adopted, with more simple mechanism, less pollution risk and high factor of safety;

(18)High compatibility, suitable for all box prefilled bottles, cartridge bottles, and vial bottles currently on the market;

(19)After plugging, the residual air volume is small, and the residual volume is less than 20μL (vacuum plug);

 

 

 

 

3. Multiple functions are optional, and customized according to your needs:

(1)The servo motor can be configured to control the filling pump for filling, with high filling accuracy and convenient adjustment;

(2)Configurable filling system CIP/SIP system;
(3)Configurable vacuum filling system for filling high viscosity products;

(4)A nitrogen filling unit can be configured to isolate the liquid medicine from oxygen;

(5)Capable of configuring high-performance no bottle no filling, no bottle no capping, and linkage bottle squeezing shutdown functions;

(6)Configurable Open-RABS isolation protection system and 100 level air purification laminar flow system;
(7)According to whether the customer's product has toxicity or activity, a fully enclosed sterile isolation (Isolator) system and a bag in bag out (BIBO) system can be configured;

(8)Multiple robot collaborative control technologies can be configured to fully automate the process of prefilled syringe film tearing, lining removal, filling, stoppering, weighing, and other related processes;

(9)The filling volume autocorrection function can be configured, and the filling volume calibration of the filling pump can be fully automated;

(10)Adopting high-precision color touch screen operation monitoring, PLC automatic control, automatic protection, mainframe variable frequency speed regulation and other control technologies for fully automatic control and monitoring of the production process;

(11)We can customize relevant products according to the actual needs of customers.

 

 

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