Pharmaceutical Industrial Laboratory Lyophilizer Liofilizador Medical Liquid Lyophilisation Equipment
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Product Details
| Customization: | Available |
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| After-sales Service: | Provided |
| Certification: | CE, GMP, ISO |
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Basic Info.
- Model NO.
- MY-FD-003
- Condition
- New
- Customized
- Customized
- Voltage
- 380V
- Power Consumption
- 15kw
- Input Capacity
- 50-70kgs/Batch
- Weight
- 3000 Kg
- Cooling Water Quantity
- >10m3/H
- Shelf Area
- 5 Square Meters
- Batch Capacity
- 20 Sets Per Month
- Type
- Preparation Machinery
- Precision
- High Precision
- Computerized
- Computerized
- Warranty
- 1 Year
- Finished Dosage Form
- Powder
- Transport Package
- Wooden Case
- Specification
- 1500*850*1600/1950 mm
- Trademark
- Marya
- Origin
- China
- Production Capacity
- 1000 Sets/Year
Product Description
Pharmaceutical Laboratory Lyophilizer Medical Liquid Lyophilisation Equipment
Main Applications
Vacuum freeze dryer its working principle is in the vacuum state, uses the sublimation principle, causes the water in the pre-freezing medicine, does not pass the ice ablation, directly rises in the ice state Huawei the water vapor is removed, thus achieves the medicine freeze-drying goal. The vacuum freeze dryer combines refrigeration system, vacuum system, heat conduction oil heating system and dehumidification system, and introduces a new type of box structure, which can be divided into laboratory freeze-drying machine, raw material freeze-drying machine, pilot production freeze-drying machine, industrial freeze-drying machine and so on. The freeze-drying products are spongy, dry-shrinking, excellent rehydration, little moisture content, and can be stored and transported at room temperature for a long time after packaging; Widely used in raw materials, Chinese medicine pieces, biological products, vaccines, blood products, active substances, antibiotics, food, fruit, chemical, pharmaceutical intermediates and other materials drying production;
Phase 1: Freezing Phase
Graph showing how a freeze dryer works and what is the ideal freeze drying pressure and freeze drying temperature
This is the most critical phase. Freeze dryers use various methods to freeze a product.
The freeze dryer cools the material below its triple point to ensure that sublimation, rather than melting, will occur. This preserves the material's physical form.
A freeze dryer most easily freeze dries large ice crystals, which can be produced by slow freezing or annealing. However, with biological materials, when crystals are too large they may break the cell walls, and that leads to less-than-ideal freeze drying results. To prevent this, the freezing is done rapidly.
For materials that tend to precipitate, annealing can be used. This process involves fast freezing, then raising the product temperature to allow the crystals to grow.
Graph showing how a freeze dryer works and what is the ideal freeze drying pressure and freeze drying temperature
This is the most critical phase. Freeze dryers use various methods to freeze a product.
The freeze dryer cools the material below its triple point to ensure that sublimation, rather than melting, will occur. This preserves the material's physical form.
A freeze dryer most easily freeze dries large ice crystals, which can be produced by slow freezing or annealing. However, with biological materials, when crystals are too large they may break the cell walls, and that leads to less-than-ideal freeze drying results. To prevent this, the freezing is done rapidly.
For materials that tend to precipitate, annealing can be used. This process involves fast freezing, then raising the product temperature to allow the crystals to grow.
Phase 2: Primary Drying (Sublimation)
The second phase is primary drying (sublimation), in which the pressure is lowered and heat is added to the material in order for the water to sublimate.
The freeze dryer's vacuum speeds sublimation. The freeze dryer's cold condenser provides a surface for the water vapor to adhere and solidify. The condenser also protects the vacuum pump from the water vapor.
About 95% of the water in the material is removed in this phase.
Primary drying can be a slow process. Too much heat can alter the structure of the material.
The second phase is primary drying (sublimation), in which the pressure is lowered and heat is added to the material in order for the water to sublimate.
The freeze dryer's vacuum speeds sublimation. The freeze dryer's cold condenser provides a surface for the water vapor to adhere and solidify. The condenser also protects the vacuum pump from the water vapor.
About 95% of the water in the material is removed in this phase.
Primary drying can be a slow process. Too much heat can alter the structure of the material.
Phase 3: Secondary Drying (Adsorption)
This final phase is secondary drying (adsorption), during which the ionically-bound water molecules are removed.
By raising the temperature higher than in the primary drying phase, the bonds are broken between the material and the water molecules.
Freeze dried materials retain a porous structure.
After the freeze dryer completes its process, the vacuum can be broken with an inert gas before the material is sealed.
Most materials can be dried to 1-5% residual moisture.
This final phase is secondary drying (adsorption), during which the ionically-bound water molecules are removed.
By raising the temperature higher than in the primary drying phase, the bonds are broken between the material and the water molecules.
Freeze dried materials retain a porous structure.
After the freeze dryer completes its process, the vacuum can be broken with an inert gas before the material is sealed.
Most materials can be dried to 1-5% residual moisture.
Notice:
Here are a few important terms related to freeze dryers.
Eutectic Point or Eutectic Temperature: The point at which the product only exists in the solid phase, representing the minimum melting temperature. Not all products have a eutectic point or there may be multiple eutectic points.
Critical Temperature: During freeze drying, the maximum temperature of the product before its quality degrades by melt-back or collapse.
Crystalline: The material forms crystals when frozen; has a eutectic point or multiple eutectic points. Fast freezing creates small crystals which are hard to dry; annealing can help form bigger crystals.
Amorphous: Multi-component mixtures which do not crystallize and do not have a eutectic point. They turn into a 'glass." Freeze drying needs to be performed below the glass transition temperature.
Collapse: The point at which the product softens to the extent that it can no longer support its own structure. This can be a problem for many reasons:
1. Loss of physical structure
2. Incomplete drying
3. Decreased solubility
4. Lots of ablation (splat)
Parameters
| Shelf temp (ºC) | -50 to 70 | ||
| Final condenser temp (ºC) | -80 | ||
| Vacuum Degree (Pa) | <10 | ||
| Condenser capacity (Kg/24h) | 15 | ||
| Qty of shelf | 4+1 | ||
| Distance between shelves(mm) | 90 | ||
| Liquid material loading capacity (L) | 20 | ||
| Cooling mode | Air cooling | ||
| Cap seal method | Hydraulic pressure | ||
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