OEM solutions for Vaccine Aseptic Filling in Vial Machine
The Marya Pharmaceutical Aseptic Vial Filling Machine line is composed of an ultrasonic bottle washing machine, dryer sterilizer, filling and sealing machine. It can complete spraying water, ultrasonic cleaning, air & water flushing of the inner and outer wall of the bottle, preheating, drying and sterilization, heat source removing, cooling, (nitrogen pre-filling), filling, (nitrogen post-filling), sealing, and other complex functions, realizing automatic production of the whole process. Each machine can be used separately or in a linkage line.
Our fillers and closers are renowned for their heavy-duty design and construction, advanced hygienic design and easy clean-ability, high operating efficiency, and operator safety. Our solutions provide the optimal combination of product quality and product safety to allow you to produce at the lowest per-unit cost.
Washing Machine
Uniform irradiation time is ensured in ultrasonic washing and vials are inverted at the washing unit for efficient washing.
Dry Sterilization Machines
Depyrogenation is performed by a hot circulation method which maintains a cleanroom class 100 status. Sterilization of the cooling unit is possible by either dry heat sterilization or gas decontamination
Filling and Rubber Stopper Machines
The double transfer rake design allows fast but stable transfer. A filling method can be selected from various types and an IPC automatic sampling unit is provided.
Sealing Machine
The load applied to the cap top is monitored for all vials to achieve stable seaming.
Performance Features
| Applicable specification |
5ml-50ml vial (as per user's requirement) |
| Production Capacity: |
6000-30000BPH |
| Number of filling head |
: 1-4, to be selected according to output |
| Filling Accuracy: |
≤ ±1% (according to drug characteristics) |
| Capping qualified rate |
≥99.9% |
1. The whole Vial Filling Stoppering Capping Machine
line meets new GMP requirements, and the cleaning effect meets the new
Pharmacopoeia standards and requirements.
2. The whole Vial Filling Stoppering Capping Machine
line can adopt a straight-line layout to reduce the risk of drug cross-contamination and ensure aseptically level.
8.Compact and simple structure occupies less area;
9.Stable product performance, easy and reliable operation, beautiful appearance;
10.High degree of automation, fewer operators required;
11.Optional real-time display and printing system of sterilization temperature;
12.The heat in the hot air circulation tunnel oven is evenly distributed, and the heat resources removal effect is good.
13.Optional online sterilization function for the cooling section of hot air circulation tunnel oven.
14. Various type of filling heads can be designed based on different filling volume, filling accuracy is high;
15. The feeding system adopts various aseptic material transfers, which meets the GMP requirements.
17. Multi-head screw intermittent filling, directly filling sterile raw materials into bottles, no secondary pollution.
18.Optional open-RABS isolation protection system and class 100 laminar flow hood protection;
19.Optional high-performance no-bottle-no-filling, no bottle no stoppering, no bottle no capping and squeeze
stop functions;
20. The capping machine can be equipped with a dust exhaust device, which can absorb aluminum
scraps produced during capping and thus reduce the risk of environmental pollution.
21. The whole line can be equipped with an online monitoring system to monitor key factors that affect product
quality (such as dust particles, planktonic bacteria, wind speed, wind pressure, etc.).
22.Full-line linkage control function;
23.To realize fully automatic control and monitor of the production process, high precision colored touch screen operation monitoring, PLC automatic control & automatic protection, main machine frequency conversion speed regulation, and other control technologies are used.
24.Applicable for a wide range of bottle specifications, and easy to replace mold.
25.The products can be customized according to the actual demand of customers.
Marya Pharmaceutical vial washing filling sealing machine
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